92 219 Caenor E4 ----MAPVTSNKAAVLDNDTVRYSRVKKNAFVRLVTNFGPLNLELFAPKVPKACENFITHCSNG------------YYNNTKFHRLIKNFMLQGGDPTGT-GHGGESIWDKPFSDE-FI-SGFSHDARGVLSMANKG-SNTNGSQFFI-TFRPCKYLDRKHTIFGRLVG--GQDTLTTIEKLETEEGTDVPMVSVVIMRAEVFV--------------- Homo C60 -------------AAIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIRLCKKH------------YYDGTIFHRSIRNFVIQGGDPTGT-GTGGESYWGKPFKDE-FR-PNLSHTGRGILSMANSG-PNSNRSQFFI-TFRSCAYLDKKHTIFGRVVG--GFDVLTAMENVESDPKTDRPKEEIRIDATTVFVDP------------- Schizosa 6------------IIAEEDYMLNHTRIKHKGYARIVTNHGEINIELHTDYAPHAVYNFVQLAKQG------------YYRNTIFHRNIARFMIQGGDPSGT-GRGGQSIWGKPFKDE-FC-NPLKHDDRGIISMANRG-KNTNGSQFFI-LYGPAKHLDNKHTIFGRVVG--GLNVLDALEKVPTNSN-DHPKLPIKLEDIIIFVD-------------- Caenor C10-----------------------------MSVTLHTTSGDIKIELYVDDAPKACENFLALCASD------------YYNGCIFHRNIKDFMVQTGDPTHS-GKGGESIWGGPFEDE-FV-SALKHDSRGCVSMANNG-PDSNRSQFFI-TYAKQAHLDMKYTLFGKVID--GFDTLEEIETIKVDNKY-RPLVQQK----------------------- Caenorha X--------------------MPAPINDQAPYVILDTTMGKIALELYWNHAPRTCQNFSQLAKRN------------YYNGTIFHRIIADFMIQGGDPTGT-GRGGASIYGDKFSDE-ID-ERLKHTGAGILSMANAG-PNTNGSQFFI-TLAPTQHLDGKHTIFGRVAA--GMKVIANMGRVDTD-NHDRPKIEIRILKAYPSESSVLS---------- Homo Ha --------------------QAEGPKRVSDSAIIHTSMGDIHTKLFPVECPKTVENFCVHSRNG------------YYNGHTFHRIIKGFMIQTGDPTGT-GMGGESIWGGEFEDE-FH-STLRHDRPYTLSMANAG-SNTNGSQFFI-TVVPTPWLDNKHTVFGRVTK--GMEVVQRISNVKVNPKTDKPYEDVSIINITVK---------------- Callipho N----LSFTVTSKIYMDVKHQKKPL--------------GRIVFGLFGKRAPKTVTNFRHIC--------LRGINGTTYVGSEFHRVISRFLIQGGDIVNNDGTGSTSIYGDFFQDE---ALDVEHLRPGYLGMANRG-PDTNGCQFYVTTV-AAQWLNGKHTVFGKVIE--GMDTVYAIEDVKTDTDDH----PIDPVIIVNCGEMPTEPYEFYPDDFS Drosophi N----LSFTVTSRIYMDVKHNKKPV--------------GRITFGLFGKLAPKTVANFRHIC--------LRGINGTSYVGSRFHRVVDRFLVQGGDIVNGDGTGSISIYGDYFPDED-KALAVEHNRPGYLGMANRG-PDTNGCQFYVTTV-GAKWLDGKHTVFGKVLE--GMDTIYAIEDVKTDTDDF----PVEPVVISNCGEIPTEQFEFYPDDFN Sacchar E1LIDQDDEVITQKVFFDIEHGEEKV--------------GRIVIGLYGKVCPKTAKNFYKLSTTTNS--------KKGFIGSTFHRVIPNFMVQGGDFTDGTGVGGKSIYGDTFPDENF---TLKHDRKGRLSMANRG-KDTNGSQFFITTTEEASWLDGKHVVFGQVVD--GMDVVNYIQHVSRDAND----KPLEAVKIAKCGEW-TPELS------- Sacchar E2EDTAEDPEITHKVYFDINHGDKQI--------------GRIVMGLYGLTTPQTVENFYQLTISRDP--------KMGYLNSIFHRVIPNFMIQGGDFTHRSGIGGKSIFGNTFKDENF---DVKHDKPGRLSMANRG-KNTNGSQFFITTV-PCPWLDGKHVVFGEVLD--GMDVVHYIENVKTDSRN----MPVKEVIIVESGELETVPLDNKDAAKL Homo Nktr SVAMGAQ-DRPQCHFDIEINREPV--------------GRIMFQLFSDICPKTCKNFLCLCSGEKGLGK-TTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGKGGESIYGGYFKDENF---ILKHDRAFLLSMANRG-KHTNGSQFFITTK-PAPHLDGVHVVFGLVIS--GFEVIEQIENLKTDAAS----RPYADVRVIDCGVLATKS--------- Mus Nktr ALAMGAQ-DRPQCHFDIEINREPV--------------GRIMFQLFSDICPKTCKNFLCLCSGEKGLGK-TTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGKGGESIYGGYFKDENF---ILKHDRAFLLSMANRG-KHTNGSQFFITTK-PAPHLDGVHVVFGLVIS--GFEVIEQIENLKTDAAS----RPYADVRVIDCGVLATKLTKDVFE--- Homo Sr ---MGIKVQRPRCFFDIAINNQPA--------------GRVVFELFSDVCPKTCENFRCLCTGEKGTGK-STQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESF---AVKHNKEFLLSMANRG-KDTNGSQFFITTK-PTPHLDGHHVVFGQVIS--GQEVVREIENQKTDAAS----KPFAEVRILSCGELIPK---------- Brugia X ----MSKKDRRRVFLDVTIDGNLA--------------GRIVMELYNDIAPRTCNNFLMLCTGMAGTGK-ISGKPLHYKGSTFHRVIKNFMIQGGDFTKGDGTGGESIYGGMFDDEEF---VMKHDEPFVVSMANKG-PNTNGSQFFITTT-PAPHLNNIHVVFGKVVS--GQEVVTKIEYLKTNSKN----RPLADVVILNCGELVRRKKRQHSSRSN Caenorha N--MPPEVRGNKRAFFDISINGEPA--------------GRIVFSLWNHCCPRTVENFRAFCTGELGKMN-GHYAS--YQGSVFHRVIKGFMIQGGDITHGNGTGGYSIYGRTFDDENL---ALKHKKPYLLSMANRG-PDTNGSQFFITSE-EVPHLDGKHCVFGEVIK--GVEVVKAIENLETGNED----KPVCKVEITHCGEMVRKGDVVGNAGAA Caenor M9 ------MAAEKRVFLDISVDENLI--------------GRIEIRLFVEDAPKTCENFRALCTGEVGMTP-NNKARLHYKQNEFHRIVKKFMIQGGDITEGDGRGGFSIYGRYFDDEKF---KLKHSRPYLLSMANKG-PNSNSSQFFITTA-AAPHCNGKHVVFGEVVK--GQNVVDYIDNLAVDDKS----KPLAKVLISNCGELV------------ Caenorm11 FAEQLRHPDNPIVFLEVTAGGAPI--------------GTIVIELFADVTPRTAENFRQFCTGEYKKD----GVPNGYKNCTFHRVIKDFMIQGGDFCNGDGTGLMSIYGSKFRDENF---ELKHIGPGMLSMANAG-SDTNGCQFFITCA-KTDFLDNKHVVFGRVL--DGMLTVRKIENVP-TGANN---KPKLPIVVVQCGQL------------- Plasmodi XLSNLLTNPSNPVVFMDINLGNHFL--------------GKFKFELFQNIVPRTSENFRKFCTGEHKIN----NLPVGYKNTTFHRVIKDFMIQGGDFVNYNGSGCISIYGEHFDDENF---DIKHDKEGLLSMANTG-PNTNGCQFFIITK-KCEWLDGKNVVFGRIIDNDSLILLKKIENVSVTPYIY---KPKIAINIVECGEL------------- Bos Ret ------KETNPVVFFDICADDEPL--------------GRITMELFSNIVPKTAENFRALCTGEKGFG---------FKSSIFHRVIPDFVCQGGDITKHDGTGGRSIYGDKFEDENF---DVKHTGPGLLSMANRG-QDTNNSQFFITLK-KAERLDFKHVVFGFVKD--GMDTVKKIESFGSPKG-----SVSRRIIITECGQI------------- Homo Ran LAAELSKETNPVVFFDVCADGEPL--------------GRITMELFSNIVPRTAENFRALCTGEKGFG---------FKNSIFHRVIPDFVCQGGDITKHDGTGGQSIYGDKFEDENF---DVKHTGPGLLSMANQG-QNTNNSQFVITLK-KAEHLDFKHVVFGFVKD--GMDTVKKIESFGSPKG-----SVCRRITITECGQI------------- Schisto C MRTKKQKRNLPRVFFDIRIGNADR--------------GRIVMELRSDIVPRTAENFRALCTGDRGFG---------YHNCCFHRVIPQFMCQGGDFVKGDGTGGKSIYGRKFDDENF---QLRHEGFGVLSMANSG-PNTNGSQFFICTT-KCDWLDGKHVVFGRVVD--GQNVVKKMESVGSKSG-----KVKEPVTISRCGELI------------ Schisto C1MRTKKQKRNLPRVFFDIRIGNGDA--------------GRIVMELRSDIVPRTAENFRALCTGERGFG---------YHNCCFHRVIPQFMCQGGDFVKGDGTGGKSIYGRKFDDENF---QLRHEGFGVLSMANSG-PNTNGSQFFICTT-KCDWLDGKHVVFGRVVD--GQNVVKKMESVGSKSG-----KVKEPVIISRCGELI------------ Neurospo C---------MSKVFFDLEWEGPVLGPNNKPTSEIKAQSGRINFTLYDDVVPKTARNFKELCTGQNGFG---------YKGSSFHRIIPEFMLQGGDFTRGNGTGGKSIYGEKFADENF---AKKHVRPGLLSMANAG-PNTNGSQFFVTTV-PTSWLDGRHVVFGEVADDESMKVVKALEATGSSSGAI---RYSKKPTIVDCGAL------------- Tolypocl XFFSATSAIMGNKVFFDIEWEGPVM-QGCKPTSTVK-QSGRINFKLYDDVVPKTAENFRALCTGEKGFG---------YEGSSFHRIIPEFMLQGGDFTRGNGTGGKSIYGEKFADENF---QLKHDRPGLLSMANAG-PNTNGSQFFVTTV-VTSWLNGHHVVFGEVADQESLDVVKALEATGSGSGAV---KYNKRATIVKSGEL------------- Candida C ---------MSTVYFDVSADGQKL--------------GKITFKLYDDVVPKTAENFRALCTGEKGFG---------YKGSIFHRVIPQFMLQGGDFTNFNGTGGKSIYGTKFADENF---VKRHDRPGLLSMANAG-PNTNGSQFFITTV-PCPWLDGKHVVFGEVTD--GLDIVKKIESFGSGSGAT---S--KKIVIEESGQL------------- Saccharo C---------MSQVYFDVEADGQPI--------------GRVVFKLYNDIVPKTAENFRALCTGEKGFG---------YAGSPFHRVIPDFMLQGGDFTAGNGTGGKSIYGGKFPDENF---KKHHDRPGLLSMANAG-PNTNGSQFFITTV-PCPWLDGKHVVFGEVVD--GYDIVKKVESLGSPSGAT---K--ARIVVAKSGEL*------------ Schizosa C---------MSNCFFDVIANGQPL--------------GRIVFKLFDDVVPKTAANFRALCTGEKGYG---------YAGSTFHRVIPQFMLQGGDFTRGNGTGGKSIYGEKFPDENF---ALKHNKPGLLSMANAG-PNTNGSQFFITTV-VTPWLDGKHVVFGEVTE--GMDVVKKVESLGSNSGAT---R--ARIVIDKCGTV------------- Saccharo M---------GKKVFFDPAVNGTKI--------------GRIEFELYDNVVPKTAENFRALCTGEKGWG---------YKGVPFHRIIPDFMIQGGDTDLTNGFGGKSIYGSKFADENF---VKKHDKAGLLSMANAG-PNTNGSQFFITTV-PCPWLDGKHVVFGEVTK--GMDIVKAIESYGTASGKP---R--AEIVIEEAGEL------------- Echinoco C---------GVKCFFDISIGGKPA--------------GRIVFALFDD-VPKTVENFRALCTGEKGFG---------YKGSKFHRIIPGFMCQGGDFTAGNGTGGKSIYGSKFEDENF---NHKHSKPMMLSMANAG-KNTNGSQFFITTA-VTSWLDGKHVVFGEVES--GEDVVKDMEAVGSSSG-----KTSQEVLITDCGQL------------- Schisto C2--------MAAKAFFDIKAGDERL--------------GRIIFELFND-VPDTTRNFRELCTHKNNFG---------YKGSVFHRIIPGFMCQGGDFTNGDGTGGKSIYGNKFKDENF---NHKH-EAFSLSMANAG-PNTNGSQFFITTV-PCSWLDGKHVVFGKVVS--GIDVVKKMESLGSTSG-----KPSKKIIIEDCGEC------------- Bos Erbc -------PSNPRVFFDVDIGGERV--------------GRIVLELFADIVPKTAENFRALCTGEKGIGP-TTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHY---KHDKEGLLSMANAG-SNTNGSQFFITTV-PTPHLDGKHVVFGQVIK--GMGVAKILENVEVKGE-----KPAKLCVIAECGELK------------ Homo 40 -------PSNPRVFFDVDIGGERV--------------GRIVLELFADIVPKTAENFRALCTGEKGIGH-TTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHY---KHDREGLLSMANAG-RNTNGSQFFITTV-PTPHLDGKHVVFGQVIK--GIGVARILENVEVKGE-----KPAKLCVIAECGELK------------ Trypanos BRPHHATVPTNPKVYFDVSIAGQAA--------------GRITFELFADAVPKTAENFRALCTGEKGFG---------YAGSGFHRIIPQFMCQGGDFTRHNGTCGKSIYGEKFPDESFAGKAGKHFGAGTLSMANAG-PNTNGSQFFICTA-PTQWLDGKHVVFGQVLE--GMDVVKAMEAVGSQGG-----STSKPVKIDSCGQL------------- Trypanos VEPHHPIVPSNPKVYFDISIGGQGA--------------GRITFELFADAVPKTAENFRALCTGEKGFG---------FANSGFHRIIPNFMCQGGDFTNHNGTGGKSIYGAKFEDESFAGKAGKHFGPGTLSMANAG-PNTNGSQFFICTA-RTQWLDGKHVVFGQVLE--GMNVVKAVEGVGSQSG-----STTKAVKIDSCGQL------------- Trypanos CKPHHPTVPTNPKVYFDITIGGTPA--------------GRITFELFADAVPKTAENFRALCTGEKGFG---------YSGSGFHRIIPNFMCQGGDFTRHNGTGGKSIYGEKFPDESFAGKAGKHFGPGTLSMANAG-PNTNGSQFFICTA-RTAWLDGKHVVFGQVLD--GMNVVEGMEAVGSQTG-----STDKPVMISESGQL------------- Oryza C1 -----MASKNPKVFFDILIGKARA--------------GRVVMELFADTVPKTAENFRCLCTGEKGLGA--SGKPLHYKGSAFHRIIPNFMCQGGDFTRGNGTGGESIYGDRFADENF---KLRHTGPGVLSMANAG-PNTNGSQFFICTT-RTTWLDGKHVVFGKVVD--GYTVVEKMEQVGSGSG-----GTAERVLIEDCGQLADDHAN------- Roc2 -----MA--NPKVFFDILIGKMKA--------------GRVVMELFADVTPRTANNFRALCTGENGIGK--AGKALHYKGSAFHRIIPGFMCQGGDFTRGNGTGGESIYGSKFEDENF---KLKHTGPGILSMANSG-PNTNGSQFFICTE-KTSWLDGKHVVFGKVVD--GYNVVKAMEDVGSDMG-----NPSERVVIEDCGELNNPSS*------- Cricetul C-------MVNPTVFFDISADGEPL--------------GRVSFELFADKVPKTAENFRALSTGEKGFG---------YKGSSFHRIIPGFMCQGGDFTRHNGTGGRSIYGEKFEDENF---ILKHTGPGILSMANAG-PNTNGSQFFICTA-KTEWLDGKHVVFGKVKE--GMNIVEAMERFGSRNG-----KTSKKITISDCGQL------------- Mus C -------MVNPTVFFDITADDEPL--------------GRVSFELFADKVPKTAENFRALSTGEKGFG---------YKGSSFHRIIPGFMCQGGDFTRHNGTGGRSIYGEKFEDENF---ILKHTGPGILSMANAG-PNTNGSQFFICTA-KTEWLDGKHVVFGKVKE--GMNIVEAMERFGSRNG-----KTSKKITISDCGQL------------- Rattus C -------MVNPTVFFDITADGEPL--------------GRVCFELFADKVPKTAENFRALSTGEKGFG---------YKGSSFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENF---ILKHTGPGILSMANAG-PNTNGSQFFICTA-KTEWLDGKHVVFGKVKE--GMSIVEAMERFGSRNG-----KTSKKITISDCGQL------------- Homo C -------MVNPTVFFDIAVDGEPL--------------GRVSFELFADKVPKTAENFRALSTGEKGFG---------YKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENF---ILKHTGPGILSMANAG-PNTNGSQFFICTA-KTEWLDGKHVVFGKVKE--GMNIVEAMERFGSRNG-----KTSKKITIADCGQLE*----------- Blattell C-------MAHPRVFFDMSADGQPV--------------GRIVMELRSDVVPKTAENFRALCTGEKGFG---------YKGSRFHRVIPNFMCQGGDFTNHNGTGGKSIYGTKFEDENF---QLKHTGPGILWMANAG-PNTNGSQFFITTA-KTSWLDNRHVVFGSVVE--GMDVVKKLESLGSQSG-----KTNKKIAVVDCGQI------------- Drosophi C------MSTLPRVFFDMTADNEPL--------------GRIVMELRSDVVPKTAENFRALCTGEKGFG---------YKGSIFHRVIPNFMCQGGDFTNHNGTGGKSIYGNKFPDENF---ELKHTGSGILSMANAG-ANTNGSQFFICTV-KTAWLDNKHVVFGEVVE--GLDVVKKIESYGSQSG-----KTSKKIIVANSGSL------------- Homo Mt ------------VYLDVDANGKPL--------------GRVVLELKADVVPKTAENFRALCTGEKGFG---------YKGSTFHRVIPSFMCQAGDFTNHNGTGGKSIYGSRFPDENF---TLKHVGPGVLSMANAG-PNTNGSQFFICTI-KTDWLDGKHVVFGHVKE--GMDVVKKIESFGSKSG-----RTSKKIVITDCGQLS------------ Rattus Mt ARGANSSSQNPLVYLDVGADGQPL--------------GRVVLELKADVVPKTAENFRALCTGEKGFG---------YKGSTFHRVIPAFMCQAGDFTNHNGTGGKSIYGSRFPDENF---TLKHVGPGVLSMANAG-PNTNGSQFFICTI-KTDWLDGKHVVFGHVKE--GMDVVKKIESFGSKSG-----KTSKKIVITDCGQLS------------ Hemicent C-------MAKPQVFFDLQANGENL--------------GRIVMELRADVVPKTAENFRALCTGEKGFG---------YKGSTFHRVIPGFMCQGGDFTRHNGTGGKSIYGEKFADENF---TLKHTQPGILSMANAG-VNTNGSQFFICTA-VTSWLDGKHVVFGAVTQ--GLDIIKKVESYGSDSG-----KTSKKITIADCGQL------------- Hirudo C ------------------------------------------MELDADVVPKTAENFRALCTGEKGFG---------YKGSSFHRVIPNFMCQGGDFTRGDGTGGKSIYGNKFEDENF---KLKHTGPGILSMANAG-KNTNGSQFFICTT-KTEWLDGKHVVFGRVVE--GLDVVKEVETFGTQSA-----SPSSRSSIADCGQL------------- Oryza C2 -------MSNTRVFFDMTVGGAPA--------------GRIVMELYAKDVPRTAENFRALCTGEKGVGK--SGKPLHYKGSTFHRVIPEFMCQGGDFTRGNGTGGESIYGEKFADEVF---KFKHDSPGILSTANAG-PNTNGSQFFICTV-PCSWLDGKHVVFGRVVE--GMDVVKAIEKVGSRGG-----STAKPVVIADCGQLS------------ Zea C -------MANPRVFFDMTVGGAPA--------------GRIVMELYANEVPKTAENFRALCTGEKGVGK--SGKPLHYKGSTFHRVIPEFMCQGGDFTRGNGTGGESIYGEKFPDEKF---VRKQPAPGVLSMANAG-PNTNGSQFFICTV-ATPWLDGKHVVFGQVVE--GMDVVKAIEKVGTRNG-----STSKVVKVADCGQLS*----------- Brassica C-------MVNPKVYFDMTVGDKAA--------------GRIVMELYADTVPETAENFRALCTGERGIGK--SGKPLHYKGSAFHRVIPKFMCQGGDFTAGNGTGGESIYGMKFKDENF---VKKHTGPGILSMRNAG-SNTNGSQFFICTE-KTSWLDGKHVVFGQVVE--GMDVVRDIEKVGSDSG-----RTSKKVVTCDCGQL------------- Roc3 ------MATNPKVYFDMTVGGKSA--------------GRIVMELYADTTPETAENFRALCTGERGIGK--QGKPLHYKGSSFHRVIPKFMCQGGDFTAGNGTGGESIYGSKFKDENF---IKKHTGPGILSMANAG-ANTNGSQFFICTE-KTSWLDGKHVVFGQVVE--GLNVVRDIEKVGSDSG-----RTSKPVVIADCGQIS------------ Roc1 -------MAFPKVYFDMTIDGQPA--------------GRIVMELYTDKTPRTAENFRALCTGEKGVGG--TGKPLHFKGSKFHRVIPNFMCQGGDFTAGNGTGGESIYGSKFEDENF---ERKHTGPGILSMANAG-ANTNGSQFFICTV-KTDWLDGKHVVFGQVVE--GLDVVKAIEKVGSSSG-----KPTKPVVVADCGQLS------------ Roc6 ------MASHPKVFFDMTIGGAPA--------------GKIVMELYTDKTPKTAENFRALCTGEKGVGR--SGKPLHFKGSSFHRVIPNFMCQGGDFTKGNGTGGESIYGAKFEDENF---ERKHTGPGILSMANAG-ANTNGSQFFICTV-KTDWLDGKHVVFGQVVE--GLDVVKAIEKIGSSSG-----KPTKPVVVADCGEISS----------- Digitali 1-------MSLPKVFFDMSIGGQPC--------------GRIVMELYADVVPKTADNFRALCTGEKGVGK--SGKPLHYKGSAFHRVIPGFMCQGGDFTAGNGTGGESIYGAKFADENF---VKKHTGPGILSMANAG-PGTNGSQFFICTE-KTAWLDGKHVVFGQVVE--GMDVVRAIEKVGSQSG-----KTAKPVVVADCGQLC------------ Digitali C-------MSNPKVFFDMTIGGQPC--------------GRIVMELYADVVPKTAENFRALCTGEKGVGK--TGKPLHYKGSAFHRVIPGFMCQGGDFTAGNGTGGESIYGAKFADENF---VKKHTGPGILSMANAG-PGTNGSQFFICTE-KTSWLDGKHVVFGQVVE--GMDVVRAIEKVGSQSG-----KTAKPVVIADCGQIC------------ Catharan C-------MPNPRVFFDMSVGGQPA--------------GRIVMELFADTTPRTAENFRALCTGEKGTGR--SGKPLHYKDSSFHRVIPGFMCQGGDFTAGNGTGGESIYGAKFADENF---IKKHTGPGILSMANAG-PNTNGSQFFICTA-KTEWLDGKHVVFGQVVE--GMDVVKAIEKVGSSSG-----RTAKKVVVEDCGQLS------------ Phaseolu C-------MPNPKVFFDMTIGGQPA--------------GRIVFELYADVTPRTAENFRALCTGEKGVGR--SGKPVHFKGSIFHRVIPNFMCQGGDFTAGNGTGGESIYGAKFADENF---VKKHTGPGILSMANAG-PGTNGSQFFICTT-KTEWLDGKHVVFGQVVE--GLDVVKDIEKVGSGSG-----KTARPVAIADCGQLS------------ Lycopers C-------MANPKVFFDLTIGGAPA--------------GRVVMELFADTTPKTAENFRALCTGEKGVGK--MGKPLHYKGSTFHRVIPGFMCQGGDFTAGNGTGGESIYGAKFNDENF---VKKHTGPGILSMANAG-PGTNGSQFFICTA-KTEWLNGKHVVFGQVVE--GMDVIKKAEAVGSSSG-----RCSKPVVIADCGQL*------------ Roc5 -------MSNPRVFFDMSLSGTPI--------------GRIEMELFADTTPNTAENFRALCTGEKGMGK--LGKPLHFKGSIFHRVIPGFMCQGGDFTAKNGTGGESIYGAKFKDENF---IKKHTGAGILSMANSG-PNTNGSQFFICTD-KTSWLDGKHVVFGQVVK--GLDVVKAIEKVGSDSG-----KTSKVVTITDCGQLS------------ Allium C ----------PRVFLTWR-SAPPA--------------GRIVMELFQDVVPQTAENFRALCTGEKGMGD--R-KPLHYKGSSFHRVIPGFMCQGGDFTAGNGTGGESIYGAKFKDENF---IKKHTGPGVLSMANAG-PGTNGSQFFICTE-KTAWLDGKHVVFGQVVE--GMDVVRAIEKVGSQSG-----QTKKPVKIADCGQLS------------ Brugia C -------MSRPKVFFDITIDGSNA--------------GRIVMELFADIVPKTAENFRCLCTGERGMGR--SGKKLHYKGSKFHRVIPNFMLQGGDFTRGNGTGGQSIYGEKFPDENF---QEKHTGLGVLSMANAG-PNTNGSQFFICTA-KTEWLDGKHVVFNRVVE--GMNVVKAVESKGSQSG-----RTSADIVISDCGQL------------- Dirofila X-------MSRPKVYFDITIDGSNA--------------GRIVMELFADIVPKTAENFRCLCTGERGVGR--SGKKLHYKGSKFHRVIPNFMLQGGDFTRGNGTGGESIYGEKFPDENF---QEKHTGPGVLSMANAG-PNTNGSQFFICTA-KTEWLDGKHVVFGRVVE--GMNVVKAIESKGSQSG-----RTSADVVITDCGQL------------- Caenor C3 -------MSRSKVFFDITIGGKAS--------------GRIVMELYDDVVPKTAGNFRALCTGENGIGK--SGKPLHFKGSKFHRIIPNFMIQGGDFTRGNGTGGESIYGEKFPDENF---KEKHTGPGVLSMANAG-PNTNGSQFFLCTV-KTEWLDGKHVVFGRVVE--GLDVVKAVESNGSQSG-----KPVKDCMIADCGQLKA----------- Caenor C7 -------MSRPRVFFDITTAGKPT--------------GRIVMELYNDIVPKTAENFRALCTGEKGVGK--SGKPLHFKGSKFHRIIPEFMIQGGDFTRGNGTGGESIYGEKFPDENF---KEKHTGPGVLSMANAG-PNTNGSQFFLCTV-KTAWLDGKHVVFGRVVE--GLDIVSKVEGNGSSSG-----TPKSECLIADCGQL------------- Onchocer X-------MTRPRVFFDITIGGQQS--------------GRIVMELFNDIVPKTAENFRALCTGEKGVGK--SGKPLHYKGSKFHRVIPNFMCQGGDFTRGNGTGGESIYGEKFEDENF---KEKHTGPGVLSMANAG-PDTNGSQFFLCTV-KTDWLDGKHVVFGRVVD--GMDVVQKIEAVGSQSG-----KTSKDVVVANCGQL------------- Caenor C2 -------MPRVKVFIDITIGGKKG--------------GRIVMELYNDIAPKTAENFRALCTGEKGKGK--SGKKLHFKGSKFHRIIPEFMIQGGDFTEGNGT-GESIHGEKFDDENF---KEKHTGPGVLSMANCG-ANTNGSQFFLCTV-KTTWLDGKHVVFGKVIE--GMDVVKAIESKGSEDG-----APSAPCVIADCGEMK------------ Dictyost CTTVKPTSPENPRVFFDITIGGVEA--------------GKVVMELYANTVPKTAENFRALCTGEKGIGK--SGKPLSYKGSSFHRVITNFMCQGGDFTMGNGTGGESIYGNKFADENF---KLKHFGQGTLSMANAG-ANTNGSQFFICVA-PTDWLDGKHVVFGFVTE--GMDVVKKMEAAGSQSG-----KTTKPVVIANCGQL------------- Caenor E1 GQSLRFASQRPKVFFDVSIGEEPA--------------GRVTMELFNDVVPKTAENFRALCTGEKGVGE--QGVALHFKGSKFHRIIPEFMIQGGDFTRHNGTGGESIYGNKFKDENF---DLKHTGPGCLSMANAG-PNTNGSQFFICTV-DTPWLDGGHVVFGQVTD--GMSVVKKIEKMGSRSG-----APAKTVTIADCGELKSE---------- Toxopla C2-------MPNPRVFFDISIDKKPA--------------GRIEFELFADVVPKTAENFRALCTGEKGTGR--SGKPLYYKGCPFHRIIPQFMCQGGDFTRMNGTGGESIYGEKFADENFSY---KHSEPFLLSMANAG-PNTNGSQFFITTV-PCPWLDGKHVVFGKVVA--GQEVVKMMEAEGRSNG-----QPKCAVEISSCGQLS------------ Athcyc ---------MAHCFFDMTIGGQPA--------------GRIIMELFPD-VPKTAENFRALCTGEKGIGP--SGKKMTYEGSVFHRVIPKFMLQGGDFTLGNGRGGESIYGAKFADENF---IHKHTTPGLLSMANAG-PGTNGSQFFITTV-ATPHLDGKHVVFGKVVE--GMDVVRKIEATQTDRGD----KPLSEVKIAKCGQL------------- Plasmod C1------MSKRSKVFFDISIDNSNA--------------GRIIFELFSDITPRTCENFRALCTGEKIGSR---GKNLHYKNSIFHRIIPQFMCQGGDITNGNGSGGESIYGRSFTDENF---NMKHDQPGLLSMANAG-PNTNSSQFFITLV-PCPWLDGKHVVFGKVIE--GMNVVREMEKEGAKSGYV---KRS--VVITDCGEL------------- Uromyces C---------MANCYFDVSSNGKPL--------------GRIVFELYDDVVPRTTNNFRQLCLNPPGKG---------FKHSIFHRVIPDFMIQGGDFTNGNGTGGESIYGKKFEDENF---QKKHVERGMLSMANAG-PNTNGSQFFITVT-KTPWLDGKHVVFGKVIEGYD-QVVKAMEKTGSQSG-----KTSSVLKIEDCGTL------------- Mroc4 EVIEPQAKVTNKVYFDVEIGGEVA--------------GRIVMGLFGEVVPKTVENFRALCTGEKKYG---------YKGSSFHRIIKDFMIQGGDFTEGNGTGGISIYGAKFEDENF---TLKHTGPGILSMANAG-PNTNGSQFFICTV-KTSWLDNKHVVFGQVIE--GMKLVRTLESQETRAFD----VPKKGCRIYACGELPLDA*-------- Vicia Ch EVAELQAKVTSKIFFDIEIGGESA--------------GRIVIGLFGDAVPKTVENFKTLSTGAKGYG---------YQGSFFHRIIPNFMIQGGDFTEGNGTGGVSIYGSKFEDESF---DLKHVGPGVLSMANAG-PNTNGSQFFICTV-PTPWLDNRHVVFGHVIE--GLDVVKQLESQETSKLDN---SPKKPCKIAKSGELPLDG--------- Schisto E1RSEANGPKVTDKVFFDIEVDGKPL--------------ARIIIGLFGKTVPKTVENFKQLSIGT---QL-KDGRTASYKGSTFHRVIKSFMIQGGDFTNHDGTGGFSIYGDRFPDENF---KLRHVGAGWLSMANAG-PDTNGSQFFITTV-KTSWLDGKHVVFGKVVE--GMNIVRQIESETTDSRDR----PVKSIKIASCGHIPVEIPFSVTNSDA Schisto JeLSEGNGPKVTEKVFFDIEVDEQPL--------------GRIIIGLFGKTVPKTVENFKQLSIGT---TL-KDGRTAAYKGSTFHRVIKSFMIQGGDFTNHDGTGGFSIYGERFPDENF---KLKHVGAGWLSMANAG-PNTNGAQFFITTT-QNPWLDGKHVVFGKVVE--GMSVVRQIENMQTDSRDR----PVKSVKIANCGHIPVDVPFSVSNTDA Homo Er2 --------VTAKVFFDVRIGDKDV--------------GRIVIGLFGKVVPKTVENFVALATGEKGYG---------YKGSKFHRVIKDFMIQGGDITTGDGTGGVSIYGETFPDENF---KLKHYGIGWVSMANAG-PDTNGSQFFITLT-KPTWLDGKHVVFGKVID--GMTVVHSIELQATDGHDR----PLTNCSIINSGKIDVKTPFVVEIADW Mus Er2 --------VTDKVFFDVRIGDKDV--------------GRIVIGLFGNVVPKTVENFVALATGEKGYG---------YKGSIFHRVIKDFMIQGGDFTARDGTGGMSIYGETFPDENF---KLKHYGIGWVSMANAG-PDTNGSQFFITLT-KPTWLDGKHVVFGKVLD--GMTVVHSIELQATDGHDR----PLTDCTIVNSGKIDVKTPFVVEVPDW Bos Er1 DEKKKGPKVTVKVYFDLRIGDEDI--------------GRVVIGLFGKTVPKTVDNFVALATGEKGFG---------YKDSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENF---KLKHYGPGWVSMANAG-KDTNGSQFFITTV-KTAWLDGKHVGFGKVLE--GMDVVRKVESTKTDGRDK----PLKDVTIADCGKIEVEKPFAIAKE-- Homo Er1 DEKKKGPKVTVKVYFDLRIGDEDV--------------GRVIFGLFGKTVPKTVDNFVALATGEKGFG---------YKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENF---KLKHYGPGWVSMANAG-KDTNGSQFFITTV-KTAWLDGKHVVFGKVLE--GMEVVRKVESTKTDSRDK----PLKDVIIADCGKIEVEKPFAIAKE-- Mus Er1 NDKKKGPKVTVKVYFDLQIGDESV--------------GRVVFGLFGKTVPKTVDNFVALATGEKGFG---------YKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENF---KLKHYGPGWVSMANAG-KDTNGSQFFITTV-KTSWLDGKHVVFGKVLE--GMDVVRKVESTKTDSRDK----PLKDVIIVDSGKIEVEKPFAIAKE-- Gallus Er DERKKGPKVTAKVFFDLRVGEEDA--------------GRVVIGLFGKTVPKTVENFVALATGEKGFG---------FKGSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGDRFPDENF---KLKHYGPGWVSMANAG-KDTNGSQFFITTV-KTAWLDGKHVVFGKVLE--GMDVVRKVENTKTDSRDK----PLKDVTIADCGTIEVEKPFAIAKE-- Rattus Er NDKKKGPKVTVKVYFDFQIGGRTC--------------RTSDLWTLWKDCSKTVDNFVALATGEKGFG---------YKNSKFHHMIKDFMIQGGDFTRGDGTGGKSIYGERFPDENF---KLKHYGPGWVSMANAG-KDTNGSQFFITTV-KTSWLDGKHVVFGKVLE--GMDVVRKVENTKTDSRDK----PLKDVIIVDCGKIEVEKPFAIAKE-- Caenor E5 GDDAKGPKVTDKVYFDMEIGGKPI--------------GRIVIGLFGKTVPKTATNFIELAKKPKGEG---------YPGSKFHRVIADFMIQGGDFTRGDGTGGRSIYGEKFADENF---KLKHYGAGWLSMANAG-ADTNGSQFFITTV-KTPWLDGRHVVFGKILE--GMDVVRKIEQTEKLPGDR----PKQDVIIAASGHIAVDTPFSVEREAV Orpinomy E---STNPKVTNKVYFDIKQGDKDL--------------GRIVLGLYGEVVPKTVENFRALATGEKGYG---------YKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFADENF---KLRHTGPGILSMANAG-RDTNGSQFFITTV-TTSWLDGRHVVFGKVIE--GMDVVTAIETTKTLPGDR----PATPVIIADCGELPVSNNNDAKAEL- Saccharo 4-------MTRPKTFFDISIGGKP--------------QGRIVFELYNDIVPKTAENFLKLCEGNAGMAKTKPDVPLSYKGSIFHRVIKDFMCQFGDFTNFNGTGGESIYDEKFEDENF---TVKHDKPFLLSMANAG-PNTNGSQAFITCV-PTPHLDGKHVVFGEVIQ--GKRIVRLIENQQCDQENN---KPLRDVKIDDCGVLPDDYQVPENAEAT Leishman ASQASADPEVTAKVYFDVMIDSEPL--------------GRITIGLFGKDAPLTTENFRQLCTGEHGFG---------YKDSIFHRVIPNFMIQGGDFTNFDGTGGKSIYGEKFADENL---KVKHF-VGALSMANAG-PNTNGSQFFITTA-PTPWLDGRHVVFGKVLD--GMDVVVRIEKTKTNSHDQ---PGEAREDRCQWRAVEREGVRWVVAVRG Plasmod C2ALCAEEHEITHKTYFDITIDDKPL--------------GRIVFGLYGKVAPKTVENFVSICKGTV-----VDGKMLHYTNSIFHRIIPNFMAQGGDITNFNGTGGLSIYGKKFEDENF---KVNHSKRGLLSMANAG-KNTNGSQFFILFI-PTPWLDGRHVVFGEV--VEGLDKLVHIEAVGTDSG-----EPLKRVLVKESGELPL----------- Theileria KPVEPSHKVTHHVHLEVQTGEKAT--------------ETLVVGLYGDLVPKTVNNFVSLCEGTK-----IGDKHYSYVDSFFHRVIPNFMVQAGDIVNGNGTGSISIYGDMFEDENF---TAKH-KKGVIAMANRG-PNTNGSQFYITTV-ATNWLDGRHVVFGEL--LEGEYTLQAIEATGTDSG-----KPSVQTVIKSCKVKKL----------- Toxopla C SGAVAENAGVRKAYMDIDIDGEHA--------------GRIILELREDIAPKTVKNFIGLFD--------------KYKGSVFHRIIPDFMIQGGDFENHNGTGGHSIYGRRFDDENF---DLKH-ERGVISMANAG-PNTNGSQFFITTV-KTEWLDARHVVFGKIT-TESWPTVQAIEALGGSGG-----RPSKVAKITDIGLLE------------ Lumbricus NETNYDPVVTHKAFFDISIGSKPI--------------GRIVFGLFADLCPYTVRNFASLVLGNTTNS---DGILLAYKSSIFHRTINNFMIQGGDFTSQNGYGGLSIYGKYFNDENF---KLCHHGFGWLGMANCG-PNTNGAQYYISTV-DTPWLDGLHNIFGIVLE--GAFVVRAIEKNPTSKGENIKDRPILAVVITDCGMLELEKPFTVPKTPV Saccharo X------MIQDPLVYLDISIDKKPI--------------GRIVCKLFREKAPKTTENFYKLCAGD-VKSPLKDQQYLSYKGNGFHRVVKNFMIQAGDIVFGTGKGGCSIYADKFEDENLG----EFVEPFTLGMANLGSPNTNNSQFFITT-YAAPHLNGKHSIFGQVVH--GKSVVRTIENCRVDSDGV----PESDVRISDCGVWE------------